Stem cell therapy is a rapidly evolving and exciting area that has already shown considerable promise in managing many degenerative conditions. Regenevéda in Chicago uses Adult Autologous Adipose, Peripheral Blood or Bone Marrow-derived Stem Cells, or Stem Cells derived from Umbilical Cord Blood.

 


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First paralyzed human treated with stem cells has now regained his upper body movement…

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Human Umbilical Cord Stem Cells

Regenevéda is now the first in the Chicagoland area to offer Human Umbilical Stem Cells as an office-based therapeutic option for all its treatments.  These cells have the advantage of youth and the experts agree that the younger the cells the better, especially when treating debilitating disease. We used banked Umbilical Stem Cells that are immunologically evasive so as not to require tissue typing or immune suppression.  And because we keep these cells on hand, you don’t have to wait. Thawing the frozen cells and administering them takes about 60-90 minutes in the office, depending on what we are treating. And while Insurance does not cover the costs of this treatment, immediate financing is available for qualified individuals. Call and set up your appointment today and find out if Stem Cells are right for you!


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What Are Adult Stem Cells and How Do They Work?

Autologous adult stem cells are derived from the same individual’s body. Adult stem cells are undifferentiated cells, found throughout the human body, that form after growth & development. Stem cells are the fundamental elements of life that can be found in all tissue of the body; connective tissues, muscle tissues, nervous tissues, and epithelial tissues. In living tissue, the main purpose of adult stem cells is to use cell division to repair and replace dying cells in order to regenerate damaged tissue. Adipose (fat) tissue has the highest concentration of stem cells and can produce billions of cells that will repair, replenish, and rejuvenate one’s body immediately.

Adult stem cells have the ability to self-renew, or divide, to replenish dying tissue of specialized cell types. They can be considered our own built-in repair systems that regenerate cells damaged by disease, injury, and everyday wear-and-tear. Once adult stem cells are administered to the body, they respond to inflammatory signals secreted by damage cells. Ultimately, adult stem cells replenish these damaged cells. Unlike traditional treatments offering less than optimal options, this revolutionary procedure gathers stem cells from their most abundant source, thus ensuring survival.

Autologous Stem Cell Transplantation

Autologous stem cell transplants typically take between 3 and 4 hours and are administered as an outpatient procedure. Doctors harvest dormant stem cells using an aspiration procedure lasting about an hour. The process of incubating, stimulating without manipulation, and infusing one’s own stem cells back into the body lasts roughly 3 to 4 hours. The side effects of adult stem cell therapy are minimal and may include irritation, such as soreness, swelling, or redness at the injection site. No negative long-term effects to this procedure have been reported. There are five steps to this treatment process in harvesting adipose tissue (fat) or bone marrow from the body:

  • PREPARATION

Using local anesthetics, our board certified surgeons prep the lower abdomen for manual mini liposuction procedure. The amount of adipose tissue to be extracted depends on which ailment is being treated; in most cases between 40-200cc is needed. Or, a bone marrow aspiration is performed under local anesthesia from your hipbone. In most cases 40-60cc of bone marrow is needed. And, some cases are suitable for stem cells derived from a sample of peripheral blood. In this case, we collect approximately 120cc of blood from the patient.

  • COLLECTION

Once the tissue is collected, the fat, blood or bone marrow is washed and centrifuged several times in a process that separates the gathered cells from the fat resulting in a potent concentration containing millions of stem cells.

  • ENRICHMENT

In some cases, blood is then taken from the patient and spun in a special centrifuge to separate the blood into its multiple parts. The blood platelets that contain growth factors are added to the stem cell concentration. This enrichment process prepares the platelet rich plasma and stem cells to be activated.

  • CELL ACTIVATION

When the stem cells are administered along with Platelet Rich Plasma (PRP), we expose the PRP to a patented laser activation process. There is some evidence to suggest that the mixture of stem cells and activated PRP is more effective at achieving the desired clinical result.

  • TRANSPLANTATION

The final step is to introduce the activated stem cells back into the body. Unlike traditional treatments offering less than optimal options, this revolutionary procedure gathers stem cells from their most abundant source and activates them to ensure their survival. The stem cells then can begin the process of potential repair, replenish the tissues, and begin rejuvenating your body immediately.

Lipogems:

The most recent addition to our stem cell related techniques is Lipogems. The Lipogems technique has been utilized in over 5,000 patients. It has recently obtained FDA clearance. Lipogems makes use of the high stem cell density of adipose tissue thought to be 1 out of every 100 cells. Lipogems utilizes mild mechanical forces in a closed system to produce micro-fractured and purified adipose tissue graft which is non expanded and ready to use in a variety of regenerative applications. More importantly, Lipogems adipose product has a very well preserved vascular stroma with slit-like capillaries wedged between adipocytes and and vascular channels. The stem cell niche is preserved enabling the pericytes to have a much higher survivability rate. The intact niche provides a perfect environment for reparative response of activated mesenchymal stem cells (MSCs). As Dr. A. Caplan has pointed out, pericytes are precursor mesenchymal stem cells. Activated MSCs are crucial for the immune modulation and regeneration. The lipoaspirate of Lipogems shows a higher percentage of mature pericytes and hMSCs than enzymatically digested lipoaspirates. We are now aware that there are novel growth factors secreted by Lipogems lipoaspirate which may explain the therapeutic efficacy of Lipogems. Also important, is the fact that the Lipogems technique may pre-serve the important MUSE cell. Muse cells are unique in that they be pluripotent, have a high survivability rate, and are quite small by stem cell standards. They are considered to be an embryonic like stem cell without any of the risks of regular embryonic stem cells since they are the patient’s own. They may represent a quantum leap in regenerative medicine. Since Lipogems preserves these cells it too is a quantum leap. Lipogems is ideal for joint disease and inflammation such as occurs in the knee, shoulder, hip and other joints. It can also be used for cosmetic procedures as the ideal filler for the face, hands and other locations.”

 

References:

Adipose Tissue and Mesenchymal Stem Cells: State of the Art and Lipogems® Technology Development.
Tremolada C, Colombo V, Ventura C.
Curr Stem Cell Rep. 2016;2:304-312. Review.

Angiogenic and anti-inflammatory properties of micro-fragmented fat tissue and its derived mesenchymal stromal cells.
Ceserani V, Ferri A, Berenzi A, Benetti A, Ciusani E, Pascucci L, Bazzucchi C, Coccè V, Bonomi A, Pessina A, Ghezzi E, Zeira O, Ceccarelli P, Versari S, Tremolada C, Alessandri G.
Vasc Cell. 2016 Aug 18;8:3. doi: 10.1186/s13221-016-0037-3.

Mesenchymal Stem Cells in Lipogems, a Reverse Story: from Clinical Practice to Basic Science.
Tremolada C, Ricordi C, Caplan AI, Ventura C.
Methods Mol Biol. 2016;1416:109-22. doi: 10.1007/978-1-4939-3584-0_6.

The Adipose Mesenchymal Stem Cell Secretome Inhibits Inflammatory Responses of Microglia: Evidence for an Involvement of Sphingosine-1-Phosphate Signalling.
Marfia G, Navone SE, Hadi LA, Paroni M, Berno V, Beretta M, Gualtierotti R, Ingegnoli F, Levi V, Miozzo M, Geginat J, Fassina L, Rampini P, Tremolada C, Riboni L, Campanella R.
Stem Cells Dev. 2016 Jul 15;25(14):1095-107. doi: 10.1089/scd.2015.0268.

A new nonenzymatic method and device to obtain a fat tissue derivative highly enriched in pericyte-like elements by mild mechanical forces from human lipoaspirates.
Bianchi F, Maioli M, Leonardi E, Olivi E, Pasquinelli G, Valente S, Mendez AJ, Ricordi C, Raffaini M, Tremolada C, Ventura C.
Cell Transplant. 2013;22(11):2063-77. doi: 10.3727/096368912X657855    

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FAQs about: Stem Cell Therapy

What are Stem Cells?

In simple terms, Stem Cells are specialized cells that are found in most of your bodies tissues whose purpose is for repairing and restoring damaged or impaired tissue as part of normal function. They can transform themselves into different types of tissues when needed. For example: Stem cells in your fat can turn into fat cells when old cells die or are damaged. They also can transform themselves into blood vessels, bone, cartilage, muscle, tendon and other types of tissues when they are harvested and relocated as occurs in a stem cell transplant or therapy.

What types of Stem Cells do you use?

We use Mesenchymal Stem Cells that are harvested from your blood, bone marrow or fat. In selected cases, we use stem cells derived from Umbilical Cord Blood.
 

How are Stem Cells harvested?

Peripheral Blood Derived Stem cells are harvested from drawing your blood. It takes about 12 tubes of blood to get sufficient numbers of Stem Cells to be clinically effective.
Bone Marrow Derived Stem Cells are harvested by aspirated bone marrow from your pelvic bone under local anesthesia.
Adipose or Fat Derived Stem Cells are harvested under local anesthesia using a liposuction technique. We need only 2 ounces of fat to obtain about 100 Million Cells.
Umbilical Cord Blood Derived Stem Cells are harvested from newborn babies cord blood. These cells are screened for all known transmissible diseases in the same way blood for transfusion is screened. The cells are then banked and stored at -86 degrees Centigrade until we need them for treatment.

Is Stem Cell Therapy approved by the FDA?

The FDA approves devices and drugs. It does not regulate treatments provided by licensed physicians. Nonetheless, the FDA has published a set of guidelines for cellular therapy. All cellular therapies offered in our clinic are administered according to the published guidelines.

What types of Stem Cells are best for me?

It depends on the condition we are treating.

Can I give my cells to my child?

Presently, the FDA does not approve of this as they consider the Stem Cells a drug in that case. That being said, we do have the ability to harvest your cells, bank them and expand them for your use down the road. When you need the Stem Cells, a portion of the expanded cells are sent directly to you for use in treatment by your physician. An interesting characteristic of these expanded cells is that they are not rejected when administered to others (as would be the case if we administered freshly harvested cells to someone else).

Can I bank my cells for use later?

We find that many of our treatments are more effective when we give repeated treatments. Think about it for a moment: When we give you a blood pressure pill, we have you take it daily, not just once. There are very few treatments in medicine where you take the treatment just once and expect it to work. In most cases, we encourage patients to let us harvest and bank their cells. Repeat treatments then are cheaper for the patient. We can give up to 20-25 additional treatments from your banked, expanded cells.

Are Stem Cell Treatments safe?

To date, in thousands of treatments using the techniques we offer, there have been no adverse effects other than minor bruising or pain at the procedure site.

Can Stem Cells develop into Cancer?

There are no known cases of this occurring using our techniques.

Why are Stem Cell Therapies so expensive?

Harvesting Stem Cells takes personnel, time, supplies and specialized reagents and equipment. The extra care and processes we use to prepare your cells for optimal effectiveness is time consuming and expensive. We want your treatment to be effective and work as well as possible. While we can never give a guarantee of success, we pride ourselves in our patients’ satisfaction. Many of our patients come back to us to treat other problems or to get even better results by repeating treatment. Quality costs. We offer the highest quality of care in the industry and treat every patient as part of our family. We want you to feel great again.

How long have you been treating patients with Stem Cells?

Dr Lobe spent over 20 years working at St. Jude on children with Stem Cell treatments for cancer and other conditions. The office procedures now offer have been available since 2010 at which time we began to offer Stem Cell therapy to our patients in the office setting.