Autism spectrum disorder (ASD) and autism are both terms for a group of disorders of brain development. With the May 2013 publication of the DSM-5 diagnostic manual, all autism disorders were merged into one diagnosis of ASD. Previously, they were recognized as distinct subtypes, including autistic disorder, childhood disintegrative disorder, pervasive developmental disorder-not otherwise specified (PDD-NOS) and Asperger syndrome. Autism is a neurodevelopmental disorder that results from maturation-related changes in various systems of the brain. Autism is highly heritable, but the cause includes both environmental factors and genetic susceptibility. In rare cases, autism is strongly associated with agents that cause birth defects. [1] Stem cell therapy is a novel and effective approach to treating autism and is based on the unique ability of stem cells to influence metabolism, immune system and restore damaged cells and tissues.

WHAT ARE THE SYMPTOMS?

Autism spectrum disorder impacts how a child perceives and socializes with others, causing problems in crucial areas of development — social interaction, communication and behavior. The severity of symptoms varies greatly, but all people with autism have some core symptoms in the areas of [2]:

  • Social interactions and relationships. Difficulty developing nonverbal communication skills. Lack of empathy and sharing enjoyment or achievements with others.
  • Verbal and nonverbal communication. Delay or lack of learning to talk. Difficulty starting and engaging in conversation.
  • Limited interests in activities or play. Preoccupation with certain topics. A need for sameness and routines.

TRADITIONAL MANAGEMENT

No cure currently exists for autism spectrum disorder. The goal of treatment is to maximize a child’s ability to function by reducing ASD symptoms and supporting development. Treatment options may include [3]:

  • Behavior and communication therapies
  • Educational therapies
  • Family therapies
  • Medications

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STEM CELL THERAPY FOR AUTISM SPECTRUM DISORDER

Autologous stem cells are theorized to have the ability to self-renew, or divide, to replenish dying tissue of specialized cell types. They are considered by some to be our own built-in repair systems that regenerate cells damaged by disease, injury, and every day wear-and-tear. Once stem cells are administered to the body, they appear to respond to inflammatory signals secreted by damage cells. Ultimately, adult stem cells are thought to replenish these damaged cells.

Attempts at stem cell therapy for autism spectrum disorder targets the brain. In autism, areas of brain regulating memory, concentration, attention, speech etc. are damaged. Stem cell management aims to improve blood and oxygen flow to the brain (improved perfusion), replaces damaged neurons and stimulates formation of the new arteries. In experiments, after some time, stem cells appear to acquire properties of cells surrounding them and multiply into these cells, which results in white and gray matter restoration. It has been proven experimentally that mesenchymal stem cells improve immune system and terminate inflammation. CD34 stimulation helps formation of the new arteries in hypoxic tissues, thus they increase blood flow in the temporal lobe and other parts of the brain. In experiments, progress is gained by restoring the impaired neuron connections and the formation of new neuron connections. Brain reactions are sped up through the improvement of synaptic transmission and development of the new neuron connections.

[4][5][6]

Anticipated improvements in autistic children after the stem cell therapy:

  • Better tolerance of different foods and improved digestion
  • More adequate behavior at home and outside
  • Less or no fear of loud noises, strangers and bright colors (gradual improvement)
  • Improved verbal skills (if the child is non-verbal, s/he is very likely to start making sounds, syllables, and then pronounce words; bigger vocabulary in verbal children)
  • Writing skills improvement or development
  • Improved self-care skills
  • Improved attention span and concentration

Though the degree of the above improvements varies, they were reported in all cases reported to date. One of the main goals of stem cell therapy is triggering brain development, and then the child’s body will do its own work. Children should be happy, and the parents are to prepare them for happy adult life by developing skills they will need the most, such as communication, self-care, educational and professional skills.

If you want to learn more about Autism and Stem Cells please feel free to contact us and discuss the matter further.

Suggested Reading    :

Mesenchymal stem cell transplantation reverses multiorgan dysfunction in systemic lupuserythematosus mice and humans.

Sun L, Akiyama K, Zhang H, Yamaza T, Hou Y, Zhao S, Xu T, Le A, Shi S.

Stem Cells. 2009 Jun;27(6):1421-32. doi: 10.1002/stem.68.

Autism spectrum disorders: is mesenchymal stem cell personalized therapy the future?

Siniscalco D, Sapone A, Cirillo A, Giordano C, Maione S, Antonucci N.

J Biomed Biotechnol. 2012;2012:480289. doi: 10.1155/2012/480289. Review.

Stem cell therapy for autism.

Ichim TE, Solano F, Glenn E, Morales F, Smith L, Zabrecky G, Riordan NH.

J Transl Med. 2007 Jun 27;5:30. Review.

Therapeutic properties of mesenchymal stem cells for autism spectrum disorders.

Gesundheit B, Ashwood P, Keating A, Naor D, Melamed M, Rosenzweig JP.

Med Hypotheses. 2015 Mar;84(3):169-77. doi: 10.1016/j.mehy.2014.12.016.

Transplantation of human cord blood mononuclear cells and umbilical cord-derived mesenchymal stem cells in autism.

Lv YT, Zhang Y, Liu M, Qiuwaxi JN, Ashwood P, Cho SC, Huan Y, Ge RC, Chen XW, Wang ZJ, Kim BJ, Hu X.

J Transl Med. 2013 Aug 27;11:196. doi: 10.1186/1479-5876-11-196.

FAQs about Autism

How is age measured?

There are several different ways to measure age. The simplest is to count the years. But we all know that your chronological age doesn’t tell the whole story. There are 56 year olds who look like they are 40 and there are other who look like they are 70. The best test of aging today appears to be a test of telomere length. As it turns out, our telomeres, the caps on the ends of the DNA strands that instruct the cells to divide can be used to give us a sense of our biological age. Another way to measure age is to look at your vascular reactivity. The greater the flexibility and thus reactivity, the younger you likely are.

How many years can you extend a persons life with anti aging measures?

This depends on how intensive a program you want and are willing to embark on. To help someone look 2-5 years younger is relatively simple. To help someone look, feel, and act 7-20 years younger is a more intense program that once started, you typically do not want to stop.

Can I be on anti aging supplements when I have a medical condition?

We take all health considerations into account when we evaluate and make treatment recommendations. It’s safe to say that everything we do takes safety into consideration. Everything is evidence based, taking into account what are the most effective ways to reduce the risk of disease. When there is any concern or contraindication for a treatment, we will advise you of your risks or advise you to discontinue specific parts of the program.
 

How long should I be on an anti aging program?

That’s like asking “How long should I keep my heart beating?” Anti aging is a lifestyle. Once you start and everyone notices how good you look and feel, why would you ever want to stop?

Are the treatments covered by insurance?

Whenever possible, we try to make use of your insurance. The fact is that few insurance companies pay for prevention or longevity. We are a cash based practice and with the exception of some consultation services, none of our treatments are covered by your insurance.